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KMID : 0359319900300030283
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Korean Journal of Veterinary Research
1990 Volume.30 No. 3 p.283 ~ p.286
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Effect of nifedipine against carrageenan - induced paw oedema in rats
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Abstract
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The effects of nifedipne and verapamil were compared on carrageenan-induced paw edema in rats and the results are summarized as follows: Carrageenan induced severe acute paw edema within 30 minutes and the maximum effect was achieved around 4 hours after administration. The carrageenan-induced paw edema was prominantly reduced by pretreatments of indomethacin (2㎎/㎏, p.o.) and nifedipine (10 and 20㎎/㎏, i.p.), whereas verapamil had no effect on the carrageenan-induced paw edema.
These results suggest that calcium antagonists, nifedipine and verapamil, have a different effect on the inflammatory response induced by carrageenan.
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